Tylosin Dosage Adjustment Based on Allometric Scaling in Male Turkeys.

ABSTRACT: Turkeys' body weight (BW) increases 10-fold within only 2.5 months, leading to a change in the pharmacokinetics (PK) of drugs according to allometric principles. Thus, the same dosage may lead to age-dependent variability in efficacy, in particular, to treatment failure and/or selection for resistance. The study aimed to investigate whether a non-linear dosage based on a published allometric model for tylosin clearance, may optimize the internal exposure in growing turkeys. The single dose PK study was performed on turkeys aged 6, 9.5, 13 and 17 weeks (BW from 1.75 kg to 15.75 kg). Tylosin was administered intravenously (i.v.) or orally (p.o.) according to following protocols: Dose = 31.6 × BW^0.58 or Dose = 158 × BW^0.58, respectively. Plasma tylosin was measured using

SUBMITTER: Pozniak B 

PROVIDER: S-EPMC8467158 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature