No Expression Divergence despite Transcriptional Interference between Nested Protein-Coding Genes in Mammals.

ABSTRACT: Nested protein-coding genes accumulated throughout metazoan evolution, with early analyses of human and Drosophila microarray data indicating that this phenomenon was simply due to the presence of large introns. However, a recent study employing RNA-seq data uncovered evidence of transcriptional interference driving rapid expression divergence between Drosophila nested genes, illustrating that accurate expression estimation of overlapping genes can enhance detection of their relationships. Hence, here I apply an analogous approach to strand-specific RNA-seq data from human and mouse to revisit the role of transcriptional interference in the evolution of mammalian nested genes. A genomic survey reveals that whereas mammalian nested genes indeed accrued over evolutionary time, they are retai

SUBMITTER: Assis R 

PROVIDER: S-EPMC8467205 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature