Bioguided Isolation of Cyclopenin Analogues as Potential SARS-CoV-2 M^pro Inhibitors from Penicillium citrinum TDPEF34.

ABSTRACT: SARS-CoV-2 virus mutations might increase its virulence, and thus the severity and duration of the ongoing pandemic. Global drug discovery campaigns have successfully developed several vaccines to reduce the number of infections by the virus. However, finding a small molecule pharmaceutical that is effective in inhibiting SARS-CoV-2 remains a challenge. Natural products are the origin of many currently used pharmaceuticals and, for this reason, a library of in-house fungal extracts were screened to assess their potential to inhibit the main viral protease M^pro in vitro. The extract of Penicillium citrinum, TDPEF34, showed potential inhibition and was further analysed to identify potential M^pro inhibitors. Following bio-guided isolation, a series of benzodiazepi

SUBMITTER: Thissera B 

PROVIDER: S-EPMC8467212 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature