High-Dose Irradiation Inhibits Motility and Induces Autophagy in Caenorhabditis elegans.

ABSTRACT: Radiation damages many cellular components and disrupts cellular functions, and was previously reported to impair locomotion in the model organism Caenorhabditis elegans. However, the response to even higher doses is not clear. First, to investigate the effects of high-dose radiation on the locomotion of C. elegans, we investigated the dose range that reduces whole-body locomotion or leads to death. Irradiation was performed in the range of 0-6 kGy. In the crawling analysis, motility decreased after irradiation in a dose-dependent manner. Exposure to 6 kGy of radiation affected crawling on agar immediately and caused the complete loss of motility. Both γ-rays and carbon-ion beams significantly reduced crawling motility at 3 kGy. Next, swimming in buffer was measured as a motility index to

SUBMITTER: Yamasaki A 

PROVIDER: S-EPMC8467272 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature