Biological Mechanism(s) Underpinning the Association between Antipsychotic Drugs and Weight Gain.

ABSTRACT: Weight gain and consequent metabolic alterations are common side-effects of many antipsychotic drugs. Interestingly, several studies have suggested that improvement in symptoms and adverse metabolic effects are correlated. We used next generation sequencing data from NT-2 (human neuronal) cells treated with aripiprazole, amisulpride, risperidone, quetiapine, clozapine, or vehicle control, and compared with the Pillinger P-score (ranked from 0 to 1, indicating greater increase in weight gain and related metabolic parameters) to identify the genes most associated with the drugs' propensity to cause weight gain. The top 500 genes ranked for their correlation with the drugs' propensity to cause weight gain were subjected to pathway analysis using DAVID (NIH). We further investigated transcript

SUBMITTER: Panizzutti B 

PROVIDER: S-EPMC8467356 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature