Sigma-1 Receptor Agonists Acting on Aquaporin-Mediated H₂O₂ Permeability: New Tools for Counteracting Oxidative Stress.

ABSTRACT: Sigma1 Receptor (S1R) is involved in oxidative stress, since its activation is triggered by oxidative or endoplasmic reticulum stress. Since specific aquaporins (AQP), called peroxiporins, play a relevant role in controlling H₂O₂ permeability and ensure reactive oxygen species wasted during oxidative stress, we studied the effect of S1R modulators on AQP-dependent water and hydrogen peroxide permeability in the presence and in the absence of oxidative stress. Applying stopped-flow light scattering and fluorescent probe methods, water and hydrogen peroxide permeability in HeLa cells have been studied. Results evidenced that S1R agonists can restore water permeability in heat-stressed cells and the co-administration with a S1R antagonist totally counteracted the ability

SUBMITTER: Pellavio G 

PROVIDER: S-EPMC8467392 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature