Sphingolipid and Endocannabinoid Profiles in Adult Attention Deficit Hyperactivity Disorder.

ABSTRACT: Genes encoding endocannabinoid and sphingolipid metabolism pathways were suggested to contribute to the genetic risk towards attention deficit hyperactivity disorder (ADHD). The present pilot study assessed plasma concentrations of candidate endocannabinoids, sphingolipids and ceramides in individuals with adult ADHD in comparison with healthy controls and patients with affective disorders. Targeted lipid analyses of 23 different lipid species were performed in 71 mental disorder patients and 98 healthy controls (HC). The patients were diagnosed with adult ADHD (n = 12), affective disorder (major depression, MD n = 16 or bipolar disorder, BD n = 6) or adult ADHD with comorbid affective disorders (n = 37). Canonical discriminant analysis and CHAID analyses were used to identify major compon

SUBMITTER: Brunkhorst-Kanaan N 

PROVIDER: S-EPMC8467584 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature