A Potential Interface between the Kynurenine Pathway and Autonomic Imbalance in Schizophrenia.

ABSTRACT: Schizophrenia is a neuropsychiatric disorder characterized by various symptoms including autonomic imbalance. These disturbances involve almost all autonomic functions and might contribute to poor medication compliance, worsened quality of life and increased mortality. Therefore, it has a great importance to find a potential therapeutic solution to improve the autonomic disturbances. The altered level of kynurenines (e.g., kynurenic acid), as tryptophan metabolites, is almost the most consistently found biochemical abnormality in schizophrenia. Kynurenic acid influences different types of receptors, most of them involved in the pathophysiology of schizophrenia. Only few data suggest that kynurenines might have effects on multiple autonomic functions. Publications so far have discussed the

SUBMITTER: Buki A 

PROVIDER: S-EPMC8467675 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature