Human Cystathionine γ-Lyase Is Inhibited by s-Nitrosation: A New Crosstalk Mechanism between NO and H₂S.

ABSTRACT: The 'gasotransmitters' hydrogen sulfide (H₂S), nitric oxide (NO), and carbon monoxide (CO) act as second messengers in human physiology, mediating signal transduction via interaction with or chemical modification of protein targets, thereby regulating processes such as neurotransmission, blood flow, immunomodulation, or energy metabolism. Due to their broad reactivity and potential toxicity, the biosynthesis and breakdown of H₂S, NO, and CO are tightly regulated. Growing evidence highlights the active role of gasotransmitters in their mutual cross-regulation. In human physiology, the transsulfuration enzymes cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE) are prominent H₂S enzymatic sources. While CBS is known to be inhibited by NO and CO, li

SUBMITTER: Fernandes DGF 

PROVIDER: S-EPMC8467691 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature