Hypothyroidism Affects Uterine Function via the Modulation of Prostaglandin Signaling.

ABSTRACT: Thyroid hormones control the functions of almost all body systems. Reproductive dysfunctions, such as abnormal sexual development, infertility, or irregularities in the reproductive cycle, might be associated with thyroid disorders. Uterine receptivity is the period when the uterus is receptive to the implantation of an embryo. During the receptivity period (implantation window), a newly formed blastocyst is incorporated into the uterine epithelium. Prostaglandins are well-known primary mediators of pathological conditions such as inflammation and cancer but are also essential for the physiology of female reproduction. The aim of this study was to evaluate the possible relationship between hypothyroidism and changes in the prostaglandin signaling pathways in the uterus and in the process o

SUBMITTER: Kowalczyk-Zieba I 

PROVIDER: S-EPMC8467780 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature