High Cell-Free DNA Integrity Is Associated with Poor Breast Cancer Survival.

ABSTRACT: A recent point of focus in breast cancer (BC) research has been the utilization of cell-free DNA (cfDNA) and its concentration (cfDConc) and integrity (cfDI) as potential biomarkers. Though the association of cfDConc and poor survival is already recognized, studies on the prognostic value of cfDI have had contradictory results. Here, we provide further evidence to support the use of cfDI as a potential biomarker. We selected 204 Eastern Finnish BC cases with non-metastatic disease and isolated cfDNA from the serum collected at the time of diagnosis before any treatment was given. The cfDConc and cfDI were measured with a fluorometer and electrophoresis and analyzed with 25 years of survival data. High cfDConc was not an independent prognostic factor in our analyses while high cfDI was foun

SUBMITTER: Lamminaho M 

PROVIDER: S-EPMC8467852 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature