Severe Traumatic Injury Induces Phenotypic and Functional Changes of Neutrophils and Monocytes.

ABSTRACT: Severe traumatic injury has been associated with high susceptibility for the development of secondary complications caused by dysbalanced immune response. As the first line of the cellular immune response, neutrophils and monocytes recruited to the site of tissue damage and/or infection, are divided into three different subsets according to their CD16/CD62L and CD16/CD14 expression, respectively. Their differential functions have not yet been clearly understood. Thus, we evaluated the phenotypic changes of neutrophil and monocyte subsets among their functionality regarding oxidative burst and the phagocytic capacity in severely traumatized patients. Peripheral blood was withdrawn from severely injured trauma patients (TP; n = 15, ISS ≥ 16) within the first 12 h post-trauma and from healthy

SUBMITTER: Janicova A 

PROVIDER: S-EPMC8467869 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature