Common Metabolites in Two Different Hypertensive Mouse Models: A Serum and Urine Metabolome Study.

ABSTRACT: Recent metabolomics studies have identified a wide array of microbial metabolites and metabolite pathways that are significantly altered in hypertension. However, whether these metabolites play an active role in pathogenesis of hypertension or are altered because of this has yet to be determined. In the current study, we hypothesized that metabolite changes common between hypertension models may unify hypertension's pathophysiology with respect to metabolites. We utilized two common mouse models of experimental hypertension: L-arginine methyl ester hydrochloride (L-NAME)/high-salt-diet-induced hypertension (LSHTN) and angiotensin II induced hypertension (AHTN). To identify common metabolites that were altered across both models, we performed untargeted global metabolomics analysis in serum

SUBMITTER: Baranwal G 

PROVIDER: S-EPMC8467937 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature