Design, Synthesis, and In Vivo and In Silico Evaluation of Coumarin Derivatives with Potential Antidepressant Effects.

ABSTRACT: In this study, a series of coumarin derivatives were designed and synthesized, their structures were characterized using nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRMS) testing methods. In the pharmacological experiment, two behavior-monitoring methods, the forced swim test (FST) and the tail suspension test (TST), were used to determine the antidepressant activity of coumarin derivatives. Compounds that showed potential activity were analyzed for their effects on 5-hydroxytryptamine (5-HT) levels in the brains of mice. Molecular docking experiments to simulate the possible interaction of these compounds with the 5-HT_1A receptor was also be predicted. The results of the pharmacological experiments showed that most coumarin derivatives exhibited sign

SUBMITTER: Wang X 

PROVIDER: S-EPMC8467986 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature