Silica@zirconia Core@shell Nanoparticles for Nucleic Acid Building Block Sorption.

ABSTRACT: The development of delivery systems for the immobilization of nucleic acid cargo molecules is of prime importance due to the need for safe administration of DNA or RNA type of antigens and adjuvants in vaccines. Nanoparticles (NP) in the size range of 20-200 nm have attractive properties as vaccine carriers because they achieve passive targeting of immune cells and can enhance the immune response of a weakly immunogenic antigen via their size. We prepared high capacity 50 nm diameter silica@zirconia NPs with monoclinic/cubic zirconia shell by a green, cheap and up-scalable sol-gel method. We studied the behavior of the particles upon water dialysis and found that the ageing of the zirconia shell is a major determinant of the colloidal stability after transfer into the water due to physisor

SUBMITTER: Naszalyi Nagy L 

PROVIDER: S-EPMC8468278 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature