Pyrroles as Privileged Scaffolds in the Search for New Potential HIV Inhibitors.

ABSTRACT: Acquired immunodeficiency syndrome (AIDS) is caused by human immunodeficiency virus (HIV) and remains a global health problem four decades after the report of its first case. Despite success in viral load suppression and the increase in patient survival due to combined antiretroviral therapy (cART), the development of new drugs has become imperative due to strains that have become resistant to antiretrovirals. In this context, there has been a continuous search for new anti-HIV agents based on several chemical scaffolds, including nitrogenated heterocyclic pyrrole rings, which have been included in several compounds with antiretroviral activity. Thus, this review aims to describe pyrrole-based compounds with anti-HIV activity as a new potential treatment against AIDS, covering the period b

SUBMITTER: Bianco MDCAD 

PROVIDER: S-EPMC8468532 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature