Characterization and Therapeutic Use of Extracellular Vesicles Derived from Platelets.

ABSTRACT: Autologous blood products, such as platelet-rich plasma (PRP), are gaining increasing interest in different fields of regenerative medicine. Although growth factors, the main components of PRP, are thought to stimulate reparation processes, the exact mechanism of action and main effectors of PRP are not fully understood. Plasma contains a high amount of extracellular vesicles (EVs) produced by different cells, including anucleated platelets. Platelet-derived EVs (PL-EVs) are the most abundant type of EVs in circulation. Numerous advantages of PL-EVs, including their ability to be released locally, their ease of travel through the body, their low immunogenicity and tumourigenicity, the modulation of signal transduction as well as the ease with which they can be obtained, has attracted incre

SUBMITTER: Spakova T 

PROVIDER: S-EPMC8468534 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature