PTGDR2 Expression in Peripheral Blood as a Potential Biomarker in Adult Patients with Asthma.

ABSTRACT:

Background

Precision medicine is a promising strategy to identify biomarkers, stratify asthmatic patients according to different endotypes, and match them with the appropriate therapy. This proof-of-concept study aimed to investigate whether gene expression in peripheral blood could provide a valuable noninvasive approach for the molecular phenotyping of asthma.

Methods

We performed whole-transcriptome RNA sequencing on peripheral blood of 30 non-atopic non-asthmatic controls and 30 asthmatic patients. A quantitative PCR (qPCR) validation study of PTGDR2 that encodes for CRTH2 receptor, expressed in cells involved in T2 inflammation, was developed in a cohort of 361 independent subjects: 94 non-asthmatic non-atopic controls, 187 asthmatic patients [including 82 with c

SUBMITTER: Garcia-Sanchez A 

PROVIDER: S-EPMC8468563 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature