Brain Renin-Angiotensin System as Novel and Potential Therapeutic Target for Alzheimer's Disease.

ABSTRACT: The activation of the brain renin-angiotensin system (RAS) plays a pivotal role in the pathophysiology of cognition. While the brain RAS has been studied before in the context of hypertension, little is known about its role and regulation in relation to neuronal function and its modulation. Adequate blood flow to the brain as well as proper clearing of metabolic byproducts become crucial in the presence of neurodegenerative disorders such as Alzheimer's disease (AD). RAS inhibition (RASi) drugs that can cross into the central nervous system have yielded unclear results in improving cognition in AD patients. Consequently, only one RASi therapy is under consideration in clinical trials to modify AD. Moreover, the role of non-genetic factors such as hypercholesterolemia in the pathophysiology

SUBMITTER: Loera-Valencia R 

PROVIDER: S-EPMC8468637 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature