Molecular RNA Correlates of the SOFA Score in Patients with Sepsis.

ABSTRACT: The most common scoring system for critically ill patients is the Sequential Organ Failure Assessment (SOFA) score. Little is known about specific molecular signaling networks underlying the SOFA criteria. We characterized these networks and identified specific key regulatory molecules. We prospectively studied seven patients with sepsis and six controls with high-throughput RNA sequencing (RNAseq). Quantitative reverse transcription PCR (RT-qPCR) confirmation was performed in a second independent cohort. Differentially and significantly expressed miRNAs and their target mRNA transcripts were filtered for admission SOFA criteria and marker RNAs for the respective criteria identified. We bioinformatically constructed molecular signaling networks specifically reflecting these criteria follow

SUBMITTER: Meidert AS 

PROVIDER: S-EPMC8468706 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature