Pharmacogenomics Variability of Lipid-Lowering Therapies in Familial Hypercholesterolemia.

ABSTRACT: The exponential expansion of genomic data coupled with the lack of appropriate clinical categorization of the variants is posing a major challenge to conventional medications for many common and rare diseases. To narrow this gap and achieve the goals of personalized medicine, a collaborative effort should be made to characterize the genomic variants functionally and clinically with a massive global genomic sequencing of "healthy" subjects from several ethnicities. Familial-based clustered diseases with homogenous genetic backgrounds are amongst the most beneficial tools to help address this challenge. This review will discuss the diagnosis, management, and clinical monitoring of familial hypercholesterolemia patients from a wide angle to cover both the genetic mutations underlying the phen

SUBMITTER: Hindi NN 

PROVIDER: S-EPMC8468752 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature