Exploring Taxifolin Polymorphs: Insights on Hydrate and Anhydrous Forms.

ABSTRACT: Taxifolin, also known as dihydroquercetin, possesses several interesting biological properties. The purpose of the study was to identify polymorphs of taxifolin prepared using crystallization in different solvents. Data from X-ray powder diffraction, differential scanning calorimetry, and thermogravimetry enabled us to detect six different crystalline phases for taxifolin. Besides the already known fully hydrated phase, one partially hydrated phase, one monohydrated phase, two anhydrous polymorphs, and one probably solvated phase were obtained. The unit cell parameters were defined for three of them, while one anhydrous polymorph was fully structurally characterized by X-ray powder diffraction data. Scanning electron microscopy and hot stage microscopy were also employed to characterize th

SUBMITTER: Stenger Moura FC 

PROVIDER: S-EPMC8469002 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature