Clonal Evolution of Multiple Myeloma-Clinical and Diagnostic Implications.

ABSTRACT: Plasma cell dyscrasias are a heterogeneous group of diseases characterized by the expansion of bone marrow plasma cells. Malignant transformation of plasma cells depends on the continuity of events resulting in a sequence of well-defined disease stages, from monoclonal gammopathy of undetermined significance (MGUS) through smoldering myeloma (SMM) to symptomatic multiple myeloma (MM). Evolution of a pre-malignant cell into a malignant cell, as well as further tumor progression, dissemination, and relapse, require development of multiple driver lesions conferring selective advantage of the dominant clone and allowing subsequent evolution under selective pressure of microenvironment and treatment. This process of natural selection facilitates tumor plasticity leading to the formation of gene

SUBMITTER: Salomon-Perzynski A 

PROVIDER: S-EPMC8469181 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature