Ontology highlight
ABSTRACT:
SUBMITTER: Jung T
PROVIDER: S-EPMC8469254 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Jung Thomas T Haist Maximilian M Kuske Michael M Grabbe Stephan S Bros Matthias M
International journal of molecular sciences 20210913 18
The advent of mitogen-activated protein kinase (MAPK) inhibitors that directly inhibit tumor growth and of immune checkpoint inhibitors (ICI) that boost effector T cell responses have strongly improved the treatment of metastatic melanoma. In about half of all melanoma patients, tumor growth is driven by gain-of-function mutations of BRAF (v-rat fibrosarcoma (Raf) murine sarcoma viral oncogene homolog B), which results in constitutive ERK activation. Patients with a BRAF mutation are regularly t ...[more]