Angelman Syndrome and Angelman-like Syndromes Share the Same Calcium-Related Gene Signatures.

ABSTRACT: Angelman-like syndromes are a group of neurodevelopmental disorders that entail clinical presentation similar to Angelman Syndrome (AS). In our previous study, we showed that calcium signaling is disrupted in AS, and we identified calcium-target and calcium-regulating gene signatures that are able to differentiate between AS and their controls in different models. In the herein study, we evaluated these sets of calcium-target and calcium-regulating genes as signatures of AS-like and non-AS-like syndromes. We collected a number of RNA-seq datasets of various AS-like and non-AS-like syndromes and performed Principle Component Analysis (PCA) separately on the two sets of signature genes to visualize the distribution of samples on the PC1-PC2 plane. In addition to the evaluation of calcium sig

SUBMITTER: Panov J 

PROVIDER: S-EPMC8469403 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature