Neuropathology and Inflammatory Cell Characterization in 10 Autoptic COVID-19 Brains.

ABSTRACT: COVID-19 presents with a wide range of clinical neurological manifestations. It has been recognized that SARS-CoV-2 infection affects both the central and peripheral nervous system, leading to smell and taste disturbances; acute ischemic and hemorrhagic cerebrovascular disease; encephalopathies and seizures; and causes most surviving patients to have long lasting neurological symptoms. Despite this, typical neuropathological features associated with the infection have still not been identified. Studies of post-mortem examinations of the cerebral cortex are obtained with difficulty due to laboratory safety concerns. In addition, they represent cases with different neurological symptoms, age or comorbidities, thus a larger number of brain autoptic data from multiple institutions would be cru

SUBMITTER: Colombo D 

PROVIDER: S-EPMC8469459 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature