The Association between Body Mass Index and Intra-Cortical Myelin: Findings from the Human Connectome Project.

ABSTRACT: Intra-cortical myelin is a myelinated part of the cerebral cortex that is responsible for the spread and synchronization of neuronal activity in the cortex. Recent animal studies have established a link between obesity and impaired oligodendrocyte maturation vis-à-vis cells that produce and maintain myelin; however, the association between obesity and intra-cortical myelination remains to be established. To investigate the effects of obesity on intra-cortical myelin in living humans, we employed a large, demographically well-characterized sample of healthy young adults drawn from the Human Connectome Project (n = 1066). Intra-cortical myelin was assessed using a novel T1-w/T2-w ratio method. Linear regression analysis was used to investigate the association between body mass index (BMI), a

SUBMITTER: Dong D 

PROVIDER: S-EPMC8469469 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature