Immunopathogenesis of Emerging Candida auris and Candida haemulonii Strains.

ABSTRACT: The emergence of a multidrug-resistant Candida species, C. auris and C. haemulonii, has been reported worldwide. In Thailand, information on them is limited. We collected clinical isolates from Thai patients with invasive candidiasis. Both species were compared with a laboratory C. albicans strain. In vitro antifungal susceptibility and thermotolerance, and pathogenesis in the zebrafish model of infection were investigated. Both species demonstrated high minimal inhibitory concentrations to fluconazole and amphotericin B. Only C. auris tolerated high temperatures, like C. albicans. In a zebrafish swim-bladder-inoculation model, the C. auris-infected group had the highest mortality rate and infectivity, suggesting the highest virulence. The c

SUBMITTER: Pharkjaksu S 

PROVIDER: S-EPMC8469599 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature