The Connection between Czc and Cad Systems Involved in Cadmium Resistance in Pseudomonas putida.

ABSTRACT: Heavy metal pollution is widespread and persistent, and causes serious harm to the environment. Pseudomonas putida, a representative environmental microorganism, has strong resistance to heavy metals due to its multiple efflux systems. Although the functions of many efflux systems have been well-studied, the relationship between them remains unclear. Here, the relationship between the Czc and Cad systems that are predominantly responsible for cadmium efflux in P. putida KT2440 is identified. The results demonstrated that CzcR3, the response regulator of two-component system CzcRS3 in the Czc system, activates the expression of efflux pump genes czcCBA1 and czcCBA2 by directly binding to their promoters, thereby helping the strain resist cadmium stress. CzcR3 can also bind to its own promot

SUBMITTER: Liu H 

PROVIDER: S-EPMC8469834 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature