Human TERT Promoter Mutations in Atypical and Anaplastic Meningiomas.

ABSTRACT:

Background

The role of telomerase reverse transcriptase (TERT) gene promoter mutations (pTERT) in atypical and anaplastic meningiomas remains controversial. This study aimed to evaluate their impact on the histologic diagnosis and prognosis in a retrospective series of 74 patients with atypical and anaplastic meningioma, including disease progression and relapse. A supplementary panel of 21 benign tumours was used as a control cohort.

Materials and methods

The mutation rate of the pTERT gene was assessed by Sanger sequencing. ATRX protein expression was detected by immunohistochemistry. The phenotypic and genotypic intra-tumour heterogeneity was studied in a sub-group of 12 cases using a Molecular Machines & Industries (MMI) CellCut laser microdissection (LMD)

SUBMITTER: Mellai M 

PROVIDER: S-EPMC8469948 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature