Antioxidant and Antiproliferative Activity of Finasteride against Glioblastoma Cells.

ABSTRACT: Glioblastoma is an actively growing and aggressive brain tumor with a high propensity of recurrence. Although the surgical removal of tumor mass is the primary therapeutic option against glioblastoma, supportive pharmacotherapy is highly essential due to incredibly infiltrative characteristic of glioblastoma. Temozolomide, an FDA-approved alkylating agent, has been used as a first-line standard pharmacological approach, but several evident limitations were repeatedly reported. Despite additional therapeutic options suggested, there are no medications that successfully prevent a recurrence of glioblastoma and increase the five-year survival rate. In this study, we tested the possibility that finasteride has the potential to be developed as an anti-glioblastoma drug. Finasteride, an FDA-appr

SUBMITTER: Kim HJ 

PROVIDER: S-EPMC8469955 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature