Ontology highlight
ABSTRACT:
SUBMITTER: Butler CR
PROVIDER: S-EPMC8469956 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20210915 18
Regioselective reactions can play pivotal roles in synthetic organic chemistry. The reduction of several 1-substituted 1,2,3-triazole 4,5-diesters by sodium borohydride has been found to be regioselective, with the C(5) ester groups being more reactive towards reduction than the C(4) ester groups. The amount of sodium borohydride and reaction time required for reduction varied greatly depending on the N(1)-substituent. The presence of a β-hydroxyl group on the N(1)-substituent was seen to have a ...[more]