Ivermectin for Prophylaxis and Treatment of COVID-19: A Systematic Review and Meta-Analysis.

ABSTRACT: Ivermectin has received particular attention as a potential treatment for COVID-19. However, the evidence to support its clinical efficacy is controversial. We undertook a new systematic review of ivermectin for the treatment and prophylaxis of COVID-19, including new primary studies, outcomes other than mortality, and grading the quality of the available evidence following the Cochrane guidance for methodology. We searched electronic databases, repository databases, and clinical trial registries (up to June 2021). The measure of treatment effect was risk difference (RD) with 95% confidence intervals (CIs). The GRADE system was used to assess the certainty of the evidence. The review includes 11 RCTs (2436 participants). The certainty of the available evidence was quite low or very low due

SUBMITTER: Cruciani M 

PROVIDER: S-EPMC8470309 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature