Serum-Derived Neuronal Exosomal miRNAs as Biomarkers of Acute Severe Stress.

ABSTRACT: Stress is the physical and psychological tension felt by an individual while adapting to difficult situations. Stress is known to alter the expression of stress hormones and cause neuroinflammation in the brain. In this study, miRNAs in serum-derived neuronal exosomes (nEVs) were analyzed to determine whether differentially expressed miRNAs could be used as biomarkers of acute stress. Specifically, acute severe stress was induced in Sprague-Dawley rats via electric foot-shock treatment. In this acute severe-stress model, time-dependent changes in the expression levels of stress hormones and neuroinflammation-related markers were analyzed. In addition, nEVs were isolated from the serum of control mice and stressed mice at various time points to determine when brain damage was most prominent

SUBMITTER: Sung M 

PROVIDER: S-EPMC8470330 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature