Novel Approach Combining Transcriptional and Evolutionary Signatures to Identify New Multiciliation Genes.

ABSTRACT: Multiciliogenesis is a complex process that allows the generation of hundreds of motile cilia on the surface of specialized cells, to create fluid flow across epithelial surfaces. Dysfunction of human multiciliated cells is associated with diseases of the brain, airway and reproductive tracts. Despite recent efforts to characterize the transcriptional events responsible for the differentiation of multiciliated cells, a lot of actors remain to be identified. In this work, we capitalize on the ever-growing quantity of high-throughput data to search for new candidate genes involved in multiciliation. After performing a large-scale screening using 10 transcriptomics datasets dedicated to multiciliation, we established a specific evolutionary signature involving Otomorpha fish to use as a crite

SUBMITTER: Defosset A 

PROVIDER: S-EPMC8470418 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature