Increased Prevalence of Celiac Disease in Patients with Cystic Fibrosis: A Systematic Review and Meta-Analysis.

ABSTRACT:

Objectives

Immune regulation seems to be altered in cystic fibrosis (CF), thus potentially predisposing patients to developing autoimmune diseases (AID). In this meta-analysis, we aimed to evaluate the prevalence of celiac disease (CeD) among CF patients as by far the most commonly reported autoimmune disease in this population and, secondly, to review the observations on other, less frequently studied autoimmune diseases.

Methods

We conducted a systematic literature search for studies that discussed AIDs among CF patients. Following standard selection and data collection, we calculated pooled raw prevalence with 95% confidence intervals (CI) for biopsy-verified CeD and seropositivity.

Results

Out of the 21 eligible studies, 15 reported on CeD. Pooled prevalence of bi

SUBMITTER: Imrei M 

PROVIDER: S-EPMC8470465 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature