The Impact of Gut Microbiota-Derived Metabolites in Autism Spectrum Disorders.

ABSTRACT: Autism Spectrum Disorder (ASD) is a set of neurodevelopmental disorders characterised by behavioural impairment and deficiencies in social interaction and communication. A recent study estimated that 1 in 89 children have developed some form of ASD in European countries. Moreover, there is no specific treatment and since ASD is not a single clinical entity, the identification of molecular biomarkers for diagnosis remains challenging. Besides behavioural deficiencies, individuals with ASD often develop comorbid medical conditions including intestinal problems, which may reflect aberrations in the bidirectional communication between the brain and the gut. The impact of faecal microbial composition in brain development and behavioural functions has been repeatedly linked to ASD, as well as ch

SUBMITTER: Peralta-Marzal LN 

PROVIDER: S-EPMC8470471 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature