In Vitro Cell Interactions on PVDF Films: Effects of Surface Morphology and Polar Phase Transition.

ABSTRACT: In recent years, several studies have validated the use of piezoelectric materials for in situ biological stimulation, opening new interesting insights for bio-electric therapies. In this work, we investigate the morphological properties of polyvinylidene fluoride (PVDF) in the form of microstructured films after temperature-driven phase transition. The work aims to investigate the correlations between morphology at micrometric (i.e., spherulite size) and sub-micrometric (i.e., phase crystallinity) scale and in vitro cell response to validate their use as bio-functional interfaces for cellular studies. Morphological analyses (SEM, AFM) enabled evidence of the peculiar spherulite-like structure and the dependence of surface properties (i.e., intra-/interdomain roughness) upon process condit

SUBMITTER: Alvarez-Perez MA 

PROVIDER: S-EPMC8470707 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature