HERV-W and Mycobacteriumavium subspecies paratuberculosis Are at Play in Pediatric Patients at Onset of Type 1 Diabetes.

ABSTRACT: The etiology of T1D remains unknown, although a variety of etiological agents have been proposed as potential candidates to trigger autoimmunity in susceptible individuals. Emerging evidence has indicated that endogenous human retrovirus (HERV) may play a role in the disease etiopathogenesis; although several epigenetic mechanisms keep most HERVs silenced, environmental stimuli such as infections may contribute to the transcriptional reactivation of HERV-Wand thus promote pathological conditions. Previous studies have indicated that also Mycobacterium avium subspecies paratuberculosis (MAP) could be a potential risk factor for T1D, particularly in the Sardinian population. In the present study, the humoral response against HERV-W envelope and MAP-derived peptides was analyzed to investigat

SUBMITTER: Noli M 

PROVIDER: S-EPMC8471288 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature