Targeted Therapies for the Evolving Molecular Landscape of Acute Myeloid Leukemia.

ABSTRACT: Despite considerable growth in our understanding of the heterogeneous biology and pathogenesis of acute myeloid leukemia (AML) in recent decades, for nearly forty years, little progress was gained in the realm of novel therapeutics. Since 2017, however, nine agents have been FDA-approved for patients with AML in both the upfront and relapsed/refractory (R/R) settings. Most of these compounds function as inhibitors of key cell cycle enzymatic pathways or mediators of leukemic proliferation and survival. They have been approved both as single agents and in combination with conventional or reduced-intensity conventional chemotherapeutics. In this article, we review the molecular landscape of de novo vs. R/R AML and highlight the potential translational impact of defined molecular disease subs

SUBMITTER: Ahmadmehrabi K 

PROVIDER: S-EPMC8471378 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature