Key Physicochemical Determinants in the Antimicrobial Peptide RiLK1 Promote Amphipathic Structures.

ABSTRACT: Antimicrobial peptides (AMPs) represent a skilled class of new antibiotics, due to their broad range of activity, rapid killing, and low bacterial resistance. Many efforts have been made to discover AMPs with improved performances, i.e., high antimicrobial activity, low cytotoxicity against human cells, stability against proteolytic degradation, and low costs of production. In the design of new AMPs, several physicochemical features, such as hydrophobicity, net positive charge, propensity to assume amphipathic conformation, and self-assembling properties, must be considered. Starting from the sequence of the dodecapeptide 1018-K6, we designed a new 10-aminoacid peptide, namely RiLK1, which is highly effective against both fungi and Gram-positive and -negative bacteria at low micromolar con

SUBMITTER: Falcigno L 

PROVIDER: S-EPMC8472000 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature