Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources.

ABSTRACT: Alzheimer's disease (AD) is a severe neurodegenerative disorder of different brain regions accompanied by distresses and affecting more than 25 million people in the world. This progressive brain deterioration affects the central nervous system and has negative impacts on a patient's daily activities such as memory impairment. The most important challenge concerning AD is the development of new drugs for long-term treatment or prevention, with lesser side effects and greater efficiency as cholinesterases inhibitors and the ability to remove amyloid-beta(Aβ) deposits and other related AD neuropathologies. Natural sources provide promising alternatives to synthetic cholinesterase inhibitors and many have been reported for alkaloids while neglecting other classes with potential cholinesterase

SUBMITTER: Tamfu AN 

PROVIDER: S-EPMC8472022 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature