Impact of G-Quadruplexes on the Regulation of Genome Integrity, DNA Damage and Repair.

ABSTRACT: DNA G-quadruplexes (G4s) are known to be an integral part of the complex regulatory systems in both normal and pathological cells. At the same time, the ability of G4s to impede DNA replication plays a critical role in genome integrity. This review summarizes the results of recent studies of G4-mediated genomic and epigenomic instability, together with associated DNA damage and repair processes. Although the underlying mechanisms remain to be elucidated, it is known that, among the proteins that recognize G4 structures, many are linked to DNA repair. We analyzed the possible role of G4s in promoting double-strand DNA breaks, one of the most deleterious DNA lesions, and their repair via error-prone mechanisms. The patterns of G4 damage, with a focus on the introduction of oxidative guanine

SUBMITTER: Pavlova AV 

PROVIDER: S-EPMC8472537 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature