Oral Peptide Vaccine against Hookworm Infection: Correlation of Antibody Titers with Protective Efficacy.

ABSTRACT: Approximately 0.4 billion individuals worldwide are infected with hookworm. An effective vaccine is needed to not only improve the health of those affected and at high risk, but also to improve economic growth in disease-endemic areas. An ideal anti-hookworm therapeutic strategy for mass administration is a stable and orally administered vaccine. Oral vaccines are advantageous as they negate the need for trained medical staff for administration and do not require strict sterility conditions. Vaccination, therefore, can be carried out at a significantly reduced cost. One of the most promising current antigenic targets for hookworm vaccine development is the aspartic protease digestive enzyme (APR-1). Antibody-mediated neutralization of APR-1 deprives the worm of nourishment, leading to redu

SUBMITTER: Shalash AO 

PROVIDER: S-EPMC8472562 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature