Inhibitory Effects of Artificial Sweeteners on Bacterial Quorum Sensing.

ABSTRACT: Despite having been tagged as safe and beneficial, recent evidence remains inconclusive regarding the status of artificial sweeteners and their putative effects on gut microbiota. Gut microorganisms are essential for the normal metabolic functions of their host. These microorganisms communicate within their community and regulate group behaviors via a molecular system termed quorum sensing (QS). In the present study, we aimed to study the effects of artificial sweeteners on this bacterial communication system. Using biosensor assays, biophysical protein characterization methods, microscale thermophoresis, swarming motility assays, growth assays, as well as molecular docking, we show that aspartame, sucralose, and saccharin have significant inhibitory actions on the Gram-negative bacteria <

SUBMITTER: Markus V 

PROVIDER: S-EPMC8472786 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature