P80 Natural Essence Exerts Efficient Anti-HIV-1- as Well as Adjuvant Effects in DCs.

ABSTRACT: Dendritic cells (DCs), as well as complement, play a major role during human immunodeficiency virus 1 (HIV-1) entry and infection at mucosal sites. Together, DCs and complement are key points for understanding host defence against HIV-1 infection and for studying the impact of new drugs on the regulation of innate host-pathogen interactions and adaptive immunity. For this, we evaluated the antiviral effect of the P80 natural essence (Longan extract) on interactions of non- and complement-opsonized HIV-1 with DCs. In viability assays, we first illustrated the effects of P80 natural essence on DC function. We found that P80 concentrations above 1.5% caused increased cell death, while at concentrations between 0.5% and 1% the compound exerted efficient antiviral effects in DCs and illustrated

SUBMITTER: Zaderer V 

PROVIDER: S-EPMC8472994 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature