Large Evolutionary Rate Heterogeneity among and within HIV-1 Subtypes and CRFs.

ABSTRACT: HIV-1 is a fast-evolving, genetically diverse virus presently classified into several groups and subtypes. The virus evolves rapidly because of an error-prone polymerase, high rates of recombination, and selection in response to the host immune system and clinical management of the infection. The rate of evolution is also influenced by the rate of virus spread in a population and nature of the outbreak, among other factors. HIV-1 evolution is thus driven by a range of complex genetic, social, and epidemiological factors that complicates disease management and prevention. Here, we quantify the evolutionary (substitution) rate heterogeneity among major HIV-1 subtypes and recombinants by analyzing the largest collection of HIV-1 genetic data spanning the widest possible geographical (100 coun

SUBMITTER: Nasir A 

PROVIDER: S-EPMC8473000 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature