Ontology highlight
ABSTRACT:
SUBMITTER: Joseph S
PROVIDER: S-EPMC8473316 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Joseph Soumya S Campbell Kevin P KP
Viruses 20210825 9
Lassa fever virus (LASV) can cause life-threatening hemorrhagic fevers for which there are currently no vaccines or targeted treatments. The late Prof. Stefan Kunz, along with others, showed that the high-affinity host receptor for LASV, and other Old World and clade-C New World mammarenaviruses, is matriglycan-a linear repeating disaccharide of alternating xylose and glucuronic acid that is polymerized uniquely on α-dystroglycan by like-acetylglucosaminyltransferase-1 (LARGE1). Although α-dystr ...[more]