Serological, Molecular and Culture-Based Diagnosis of Lentiviral Infections in Small Ruminants.

ABSTRACT: Small ruminant lentiviruses (SRLVs) infections lead to chronic diseases and remarkable economic losses undermining health and welfare of animals and the sustainability of farms. Early and definite diagnosis of SRLVs infections is the cornerstone for any control and eradication efforts; however, a "gold standard" test and/or diagnostic protocols with extensive applicability have yet to be developed. The main challenges preventing the development of a universally accepted diagnostic tool with sufficient sensitivity, specificity, and accuracy to be integrated in SRLVs control programs are the genetic variability of SRLVs associated with mutations, recombination, and cross-species transmission and the peculiarities of small ruminants' humoral immune response regarding late seroconversion, as w

SUBMITTER: Kalogianni AI 

PROVIDER: S-EPMC8473411 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature