Pathology, tissue tropism and antibody response of nephropathogenic infectious bronchitis virus (IBV) Indian isolate in experimentally infected chicken.

ABSTRACT: Infectious bronchitis virus isolate (IND/AHL/16/01) from a disease outbreak characterized by nephritis, gout and mortality in coloured layer pureline at Directorate of Poultry Research, India was characterized as nephropathogenic strain by S1 genotyping and phylogenetic analysis. Serotyping with homologous and heterologous serum (M41) by virus neutralization assay in embryonated chicken eggs (ECE) showed indices of 7.3 and 2.3 respectively. Pathogenesis, tissue tropism and host immune response induced by this isolate were investigated in experimentally infected chicken. A total of 150, twenty days old seronegative Vanaraja birds were inoculated through intranasal and intravenous route using 10^4.7 Embryo infective dose₅₀ (EID₅₀/ml). Infected chickens were sa

SUBMITTER: Kannaki TR 

PROVIDER: S-EPMC8473506 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature